منابع مشابه
Bacterial Exotoxins and the Inflammasome
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. In certain myeloid cells, this activation can also lead to an inflammatory cell death (pyroptosis). Inflammasome sensor proteins have ...
متن کاملBacterial recognition pathways that lead to inflammasome activation
Inflammasomes are multi-protein signaling platforms that upon activation trigger the maturation of the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18, and cell death. Inflammasome sensors detect microbial and host-derived molecules. Here, we review the mechanisms of inflammasome activation triggered by bacterial infection, primarily focusing on two model intracellular bacterial pa...
متن کاملThe inflammasome: Learning from bacterial evasion strategies.
The innate immune system plays a critical role in defense against microbial infection and employs germline-encoded pattern recognition receptors to detect broadly conserved microbial structures or activities. Pattern recognition receptors of the nucleotide binding domain/leucine rich repeat (NLR) family respond to particular microbial products or disruption of cellular physiology, and mediate t...
متن کاملEvaluation of the Expression of NLRP1 Inflammasome in Patients with Bacterial Septicemia
Background: Septicemia is the most important cause of mortality, especially in hospitalized patients, due to the influence of the immune response by infection. NLRP1 (Nod-like receptor P1) is an intracellular receptor that recognizes microbial-dependent molecular patterns. The main intracellular mechanism of anti-septicemia is still being investigated. The purpose of this study was to evaluate ...
متن کاملLeukocyturia, another clue to inflammation in acute coronary syndrome
Introduction: Cronary artery disease is the main cause of mortality in developed countries. Classic risk factors have not been able to explain epidemiologic variants in this disease, hence other risk factors including systemic infections are under survey. This study was designed to evaluate the possible role of local and systemic infections in producing acute coronary syndrome (ACS). Methods: ...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2012
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.2278